Cart
sales@molnova.com
PD153035 hydrochloride
CAS No. 183322-45-4
PD153035 hydrochloride ( AG-1517 )
Catalog No. M12831 CAS No. 183322-45-4
PD153035 hydrochloride (ZM 252868; AG 1517) is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect against PGDFR, FGFR, CSF-1, InsR and Src.
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 56 | In Stock |
|
| 25MG | 113 | In Stock |
|
| 50MG | 221 | In Stock |
|
| 100MG | 375 | In Stock |
|
| 500MG | 853 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePD153035 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionPD153035 hydrochloride (ZM 252868; AG 1517) is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect against PGDFR, FGFR, CSF-1, InsR and Src.
-
DescriptionPD153035 hydrochloride (ZM 252868; AG 1517) is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect against PGDFR, FGFR, CSF-1, InsR and Src.
-
SynonymsAG-1517
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR; EGFR
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number183322-45-4
-
Formula Weight396.67
-
Molecular FormulaC16H15BrClN3O2
-
Purity>98%(HPLC)
-
SolubilityDMSO: 0.5 mg/mL (1.26 mM)
-
SMILESCOc(c1)c(OC)cc2c1ncnc2Nc3cc(Br)ccc3.Cl
-
Chemical NameN-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Fry DW, et al. Science. 1994, 265(5175), 1093-1095.
molnova catalog
related products
-
HKI-357
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM). HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
-
Lapatinib ditosylate
A reversible, selective dual tyrosine kinase inhibitor of both EGFR and ErbB2 with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively.
-
Beta-Hydroxyisovaler...
Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly decreased viability of HCT116 cells (IC50 values = 30.9 μg/mL).
